I have made so many over the years hard to pin down one...

1) Thinking I can ever control mother nature. For example

Pond has become infested with bullheads.
Step 1) Take a class to get my RUP license.
Step 2) Buy Rotenone (spend money)
Step 3) Apply Rotenone and watch all my "good" fish parish with those bad whiskered fish
Step 4) Clean up mess
Step 5) Restock "good" fish (spend more money)
Step 6) Wait for growth
Step 7) The entire process, along with money and time, a waste. They came back.

Work with mother nature and understand if it happened once, it's most certainly going to happen again