Yes it will run it's course from my personal experience and all the literature I have read.
Is there anything stressing your fish that is bringing this about? Most pathogens are ubiquitous to your water (scientific term is facultative), and only rear their ugly head with something is stressing your fish. High water temps, temp swings, low oxygen, herbicide treatment, too many fish, spawning activity, not enough to eat, old fish feed, added fish from another body of water recently etc.?
