I'd like to add a question to his post above.
Is the 2,4-D a systemic poison like Renovate OTF, or is it like Diquat? Will 2,4-D kill the roots as well, or just burn off the tops leaving it ready to pop back up next year?
I used diquat last year and while it killed the milfoil, it's back again this year. I have smaller patches than Bassman70, so I'm going to hand pull the individual plants, then hit those areas with a systemic poison in a month. Hopefully that will be the end of it.