first one ruger 10/22, plenty of ammo choices, subsonic hollow point serves many practical purposes

2nd and my favorite, a .223 in a jprifle set up http://www.jprifles.com/1.2.2_JP15.php, it's not really a rifle, it's a piece of art

3rd .308 in a jp

now you need to include bolt rifles

and as DD mentioned, one can never have too many handguns

but to keep things simple and effective the jp rifle in .223 with a suppressor is my overall top pick, because eliminating problems quietly, solves many of the world's problems quickly