There is a lot of research into Vitamin D deficiency both in humans and animals/fish. It is a hotly debated topic in my circles. There is interesting information (but not much research) on Vit D levels in farm raised fish vs wild caught fish. Dr. Wetzel could probably speak to this.
There have been lots of stories about medical offices where one provider makes sure all their patients get adequate D supplementation to blood levels of 50ng/dl or higher. Although it is not a controlled trial, the number of influenza cases in the group with adequate D vs those with no supplements is quite remarkable (like close to zero vs the typical seasonal load of sick influenza patients)
To me it is fascinating (as is the article I'll attach for those who would like to wade through a more scientific explanation). But to get to the real answers you need long term randomized and blinded studies. This costs money and the people who sell Vitamin D will never be able to pay to run the study so we probably will never know the true answers.
But it also explains well the original questions at the beginning of this thread, which is, if Influenza virus is in every locality all year, why is it only seen causing troubles mainly in the winter months?
It makes sense in our northern community that influenza activity always peak when the UV exposure totals are lowest (meaning least amount of sunlight for the most days) which also correlates well with the low point in everyone's D levels (for those who don't take D supplements). It also explains fairly well why Australia has influenza during our summer and not at the same time as we do. If the outbreaks were from people living close together, sharing offices in the winter, travelling on airplanes more etc then with global travel we should see outbreaks across the globe in the same weeks of the year like we do with other outbreaks like ebola, etc.
But since it depends on a 'seasonal' factor, which makes sense could be the angle of the sun and temperature which affects how much skin is covered with clothing and the UV factor, which then affects your blood D levels, then it all starts fitting together. The article below said that Hippocrates nailed it hundreds of years before Christ stating that if you want to understand the disease at hand, you have to understand the season of the year as well.
Again, I don't push vitamins or suggest this Vitamin as the be-all answer, but for me it answers a lot of questions and I make sure my family, relatives, especially elderly and young children are not low on Vit D. I see no real risk of toxicity and see no reason to knowingly and purposely keep a Vitamin our bodies need at a very low level. I'm surprised that few know of this, or know of their personal Vit D level.
The Vit D Guru Dr. Cannell and his well written article.