If I had a very large body of water and couldn't aerate the entire BOW would creating "safe zones of DO" work? Will the majority of the fish find these zones? Assume the BOW is shaped like a fish bowl

Fish do detect and move to optimum DO locations. That does not mean partial DO aeration methods will not cause other problems.

I agree with Eric. Fish do sense DO. But, that doesn't mean they have the sense to escape a large area of lower lethal DO. On several occasions I've seen entire coves of fish die from a DO crash, while other parts of the lakes escaped that dilemma. That happens in larger ponds and lakes.
For your question, presuming the bowl-shape, and with the DO curves truly as you drew it, fish will escape the 2 ppm DO (I'm assuming that's the bottom of that hypothetical pond) and stay above it. From 3ppm and up, they can survive and won't necessarily choose the highest DO. Fish only need what DO they need to breathe. Beyond that, they'll choose the best temperature, every time.
In a recent issue of Pond Boss, we have an article describing a specific situation where temperature caused fish death, while oxygen was optimized. This was a case last summer where an enthusiastic pondmeister was moving too much water and the temperature rose too high. Fish didn't have a thermal refuge and some of them perished.

IMO Safe zones with higher DO will allow some or more fish to survive killing DO situations. Keep in mind that the DO concentration and area size in the safe zone is not constant. The big variables are wind direction and water temperature. From my observations when DO is at or near a kill concentration, the fish wander aimlessly about usually at the surface struggling or searching for higher DO. This behavior is commonly observed during pond renovations with rotenone that causes DO stress and death. I see similar fish behavior during natural fish kills.

I have a comment about the right figure (1ac pond) noted above. I think the DO concentrations of an aerated pond are rarely as pictured. This is because the water near the shore is shallow. Shallower water has more plants either rooted or attached algae that can receive light and then these plants normally make adequate DO to keep the shallow illuminated areas higher in DO compared to mid water zones. An adequately sized aerator can/will during the turnover process pull water from the more remote marginal areas down the pond slope and into the boil to then blend & lift the water to the surface where it can be degassed and oxygenated.

Thank you gentlemen!

The waters I am dealing with are pretty shallow (less than 8'). So mixing of the water in a large surface acreage BOW will be a real challenge, especially with tight budget constraints. I ran out of winter quickly this year but I believe this is what I will find in my testing next winter. Pockets of higher DO based on the limitations the type of aeration system I am running.

I should have been a more specific in my question. Ice covered waters is when these higher pockets of DO will be created.

Then you will need to watch for super cooling. Which can kill fish.. There is a lot here on hard water (ice) aeration and the methods , limitations and suggestions.

Several years ago, an entire issue of the PB Mag was devoted to aeration with articles from vendors. Something like that ought to be resurrected.

I sure hope they can find the pockets of DO, otherwise mine are probably all DEAD!