They make pistols (5 shot) and derringers (2 shot) that will shoot 410 shells (from bird shot to slugs) and also shoot 45 colt ammo. Some will shoot 3 inch 410 and 45 long colt others standard 410 and 45 colt. Not that it would be my choice but it would be a very good one.
The most effective and dangerous weapon is a creative human mind.